Synthesis And Study Of Oxasmaragdyrin Dyads

SYNTHESIS AND STUDY OF OXASMARAGDYRIN DYADS

M.Sc. Project

Final Stage

By:

Sukumar Honkote

Roll No. 07103014

5th year Integrated M.Sc. Student

Department of Chemistry

Supervisor:

Professor M. Ravikanth

Department of Chemistry

Certificate

I certify that the work presented in this report submitted by Sukumar Honkote (Roll. No. 07103014) has been carried out under my supervision

Date:

Supervisor,

Prof. M. Ravikanth,

Department of Chemistry,

IIT Bombay

Table of Contents

Introduction…………………………………………………………………………………………………………………...4

Part 1

1.1 Motivation……………………………………………………………………………………………………………….6

1.2 Methods and Materials…………………………………………………………………………………………….8

1.3 Results and Discussion…………..………………………………………………………………………………11

1.4 Experimental Section……………………………………………………………………………………………..16

1.5 Conclusion……………………………………………………………………………………………………………18

Part 2

2.1 Motivation……………………………………………………………………………………………………………19

2.2 Methods and Materials…………………………………………………………………………………………..20

2.3 Results and Discussion…………………………………………………………………………………………..23

2.4 Experimental Section……………………………………………………………………………………………..25

2.5 Conclusion………………………………………………………………………………………………………….....27

References……………………………………………………………………………………………………………………28

Acknowledgements………………………………………………………………………………………………………30

INTRODUCTION

P

orphyrin ring forms the core of several biological systems as cofactors at the active sites of enzymes chelating with the metal ions like Cytochrome P-450, NADPH oxidase. But porphyrin enjoys the status of life endowing agent by being part of chlorophyll and hemoglobin. The macrocyclic aromatic core is formed by 18π electrons in resonance resulting in interesting fluorescent properties. Due to this, porphyrin has high absorption in the visible region and is colored. Porphyrin can bind tetradentately with most metals, even lead which does not even fit in the core1. The stability of porphyrin in exacting conditions als...